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Changing Sensitivity of the Pubertal Gonadal Hypothalamic Feedback Mechanism in Man

1969; American Association for the Advancement of Science; Volume: 166; Issue: 3908 Linguagem: Inglês

10.1126/science.166.3908.1012

1095-9203

Howard E. Kulin, Melvin M. Grumbach, Selna L. Kaplan,

Stress Responses and Cortisol

Clomiphene citrate in doses which stimulate gonadotropin production in the adult suppresses urinary follicle stimulating hormone (FSH) excretion and plasma testosterone concentration in prepubertal children. Such results indicate that feedback between gonad and hypothalamus is operative and highly sensitive in prepubertal humans. Puberty in man, as in the rat, is accompanied by a decrease in the sensitivity of the feedback mechanism.