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Discordance of signs in monozygotic twins concordant for the goldenhar anomaly

1988; Wiley; Volume: 29; Issue: 4 Linguagem: Inglês

10.1002/ajmg.1320290404

1096-8628

C. Anthony Ryan, Neil N. Finer, Elizabeth Ives, John M. Optiz, James F. Reynolds,

Head and Neck Surgical Oncology

Abstract Concordance for Goldenhar anomaly has been described in monozygotic(MZ) twins on 2 occasions but never in dizygotic (DZ) twins. In both cases the twins were similarly, although not identically, affected. We report on a pair of probably monozygotic twins (8% probability of DZ) who presented with extremely diverse manifestations of this anomaly complex. One of them required a tracheostomy because of obstructive apnea due to severe micrognathia and subsequently died. This twin had a midline lower lip cleft which has not previously been described in the Goldenhar anomaly.