Structure d'une lactone allergisante: Le frullanolide—I
1972; Elsevier BV; Volume: 28; Issue: 23 Linguagem: Francês
10.1016/s0040-4020(01)88923-7
ISSN1464-5416
AutoresG. W. Perold, J.-C. Muller, Guy Ourisson,
Tópico(s)Lichen and fungal ecology
ResumoLes Frullaines (Hépatiques, Jungermanniales) sont cause d'allergies. L'extraction de Frullania tamarisci a donné la friedeline et, comme seul composé allergisant isolé, une lactone sequiterpénique: le (−)-frullanolide, dont la structure est établie. L'énantiomère dextrogyre de cette lactone a été isolé de Frullania dilatata. Le pouvoir allergisant est intimement lié à la présence du groupement α-méthylène-γ-butyrolactone. Frullania spp. (Hepaticae, Jungermanniales) are widespread allergy-inducing epiphytes. Extraction of Frullania tamarisci led to isolation of friedelin and of an allergenically active sesquiterpene lactone: (−)-frullanolide, the structure of which has been elucidated. The dextrorotatory enantiomer of this lactone was isolated from Frullania dilatata. The allergenic properties observed are linked with the presence of the α-methylene-γ-butyrolactone.
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