Studies on the mechanism of intestinal absorption of sugars VI. The specificity and other properties of Na+-dependent entrance of sugars into intestinal tissue under anaerobic conditions, in vitro
1962; Elsevier BV; Volume: 59; Issue: 1 Linguagem: Inglês
10.1016/0006-3002(62)90700-x
ISSN1878-2434
AutoresI. Bihler, Kenneth A. Hawkins, Robert K. Crane,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoMeasurements in vitro of anaerobic sugar entrance into the tissue of hamster small intestine have established the existence of a specific, Na+-dependent and energy-independent process mediating the rapid equilibration of certain sugars between the tissue and the medium. This process appears to be a component of the aerobic active-transport mechanism. It shares with active transport a dependence on the Na+ concentration in the medium, a location at the brush-border pole of the epithelial cells and an apparently identical substrate specificity. The entrance into the tissue of a new analog, 6-deoxy-1,5-anhydro-d-glucitol, was found to be Na+-dependent, thus confirming the previously derived specificity pattern of active transport.
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