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Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis

2014; Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia; Volume: 29; Issue: 10 Linguagem: Inglês

10.1590/s0102-8650201400160007

1678-2674

José Roosevelt Cavalcante, João Paulo Aguiar Sampaio, João Tarcísio Alves Maia Filho, Renato Braga Vieira, José Eleutério, Roberto César Pereira Lima Júnior, Ronaldo A. Ribeiro, Paulo Roberto Carvalho Almeida,

Cancer-related gene regulation

PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.