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BIBTEX RIS

The HBZ gene, a key player in HTLV-1 pathogenesis

2009; BioMed Central; Volume: 6; Issue: 1 Linguagem: Inglês

10.1186/1742-4690-6-71

ISSN

1742-4690

Autores

Masao Matsuoka, Patrick L. Green,

Tópico(s)

Animal Disease Management and Epidemiology

Resumo

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.

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