Nucleophilic substitution by 3‐amino‐1,2‐propanediol in nitropyrazines and nitroquinoxalines
1983; Wiley; Volume: 20; Issue: 4 Linguagem: Inglês
10.1002/jhet.5570200419
ISSN1943-5193
AutoresGeorge D. Hartman, J. E. SCHWERING,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoAbstract Treatment of 2‐chloro‐3‐nitropyrazine and 2‐chloro‐5‐nitropyrazine with 3‐amino‐1, 2‐propanediol affords products derived from displacement of chloride, while similar reaction of methyl 3‐nitropyrazinoate and 2‐chloro‐3‐nitroquinoxaline gives clean nitro group replacement. Analogous reaction of methyl 6‐chloro‐3‐nitropyrazinoate affords a mixture containing products derived from competitive displacement of chloride and nitrite.
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