Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity
2009; Elsevier BV; Volume: 17; Issue: 17 Linguagem: Inglês
10.1016/j.bmc.2009.07.050
ISSN1464-3391
AutoresR.C. Santos, Jorge A. R. Salvador, Silvia Marín, Marta Cascante,
Tópico(s)Phytochemistry and Biological Activities
ResumoA series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives of betulin and betulinic acid (14–29) have been synthesized. The new compounds were screened for in vitro cytotoxicity activity against human cancer cell lines HepG2, Jurkat and HeLa. A number of compounds have shown IC50 values lower than 2 μM against the cancer cell lines tested and the vast majority has shown a better cytotoxicity profile than betulinic acid, including the betulin derivatives. N-Acylimidazole derivatives 26 and 27 (IC50 0.8 and 1.7 μM in HepG2 cells) and the C-3 carbamate derivative 16 (IC50 2.0 μM in HepG2 cells) were the most promising compounds. Based on the observed cytotoxicity, structure–activity relationships have been established.
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