Evaluation of a Low-Dose Nonoxynol-9 Gel for the Prevention of Sexually Transmitted Diseases
2001; Lippincott Williams & Wilkins; Volume: 28; Issue: 7 Linguagem: Inglês
10.1097/00007435-200107000-00006
ISSN1537-4521
AutoresBarbra A. Richardson, Ludo Lavreys, Harold Martin, Claire E. Stevens, Elizabeth Ngugi, Kishorchandra Mandaliya, Job J. Bwayo, Jeckoniah Ndinya‐Achola, Joan K. Kreiss,
Tópico(s)Sex work and related issues
ResumoBackground Low-dosenonoxynol-9 products have a potential advantage of reduced toxicity. However,little is known about their efficacy in reducing the incidence of sexuallytransmitted diseases(STDs). Goal Todetermine the effect that an intravaginal gel containing 52.5 mg ofnonoxynol-9 has on the acquisition of STDs in a cohort ofHIV-1–seronegative female sex workers in Mombasa,Kenya. StudyDesign A randomized double-blind placebo controlled trialwasperformed. Results Inthis study, 139 women were randomized to the nonoxynol-9 group and 139 to theplacebo group. No significant differences were found between the two studygroups in terms of safety outcomes and reported symptoms, except for a lowerincidence of vaginal erythema in the nonoxynol-9 group. There was asignificantly higher incidence of gonorrhea in the nonoxynol-9 group than inthe placebo group. No significant differences were observed between the groupsfor acquisition of Candida, trichomonas, bacterial vaginosis, Ctrachomatis, syphilis, or HIV-1, although the statistical power todetect differences for some of these STDs waslimited. Conclusions Inthis randomized placebo-controlled trial of a low-dose nonoxynol-9 gel, asignificantly higher incidence of gonorrhea was found in the nonoxynol-9group, but no significant differences between the groups were found for Candida, trichomonas, bacterialvaginosis, C trachomatis, syphilis, orHIV-1.
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