Effects of melatonin and propranolol on sleep of the rat
1980; Elsevier BV; Volume: 201; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(80)90793-3
ISSN1872-6240
AutoresWallace B. Mendelson, J. Christian Gillin, Susan Dawson, Alfred J. Lewy, Richard Jed Wyatt,
Tópico(s)Sleep and related disorders
ResumoMelatonin and l-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. l-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. l-propranolol produced decreased in percentage REM sleep at both times.
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