An Improved Synthesis of Bis(Trimethylsilyl)Chloromethane
1981; Taylor & Francis; Volume: 11; Issue: 6 Linguagem: Inglês
10.1080/00945718108056002
ISSN1532-2440
AutoresA. H. Cowleya, Richard A. Kemp,
Tópico(s)Organoboron and organosilicon chemistry
ResumoAbstract A new “one pot” synthesis of the important intermediate, (Me3Si)2CHCl, is described. The method involves the reaction of CH2Cl2, Me3SiCl2, and n-BuLi in a mixed solvent system. The overall yield of (Me3Si)2CHCl based upon the CH2Cl2 consumed is 78%. Apart from the obvious advantage of being a single step procedure, the method also has the advantage of utilizing relatively inexpensive starting materials. Moreover, the method can be scaled up without significant diminution of the yield.
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