Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid
1994; Elsevier BV; Volume: 5; Issue: 12 Linguagem: Inglês
10.1016/s0957-4166(00)80390-0
ISSN1362-511X
AutoresRandall L. Halcomb, Wolfgang Fitz, Chi‐Huey Wong,
Tópico(s)Pharmacological Effects of Natural Compounds
Resumo7-Deoxy-N-acetylneuraminic Acid and 7-O-methyl-N-acetylneuraminic acid were synthesized through the sialic acid aldolase-catalyzed aldol addition reactions of 4-deoxy-N-acetyl-D-mannosamine and 4-O-methyl-N-acetyl-D-mannosamine, respectively, with pyruvate. The obtained sialic acids will be used as probes for the investigation of the unusual mechanism of a novel sialidase from leech.
Referência(s)