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Function and Expression of Ultrabithorax in the Drosophila Embryo

1985; Cold Spring Harbor Laboratory Press; Volume: 50; Linguagem: Inglês

10.1101/sqb.1985.050.01.025

1943-4456

Michael Akam, Alfonso Martínez-Arias, Robert O. J. Weinzierl, C. Deborah Wilde,

Genomics and Chromatin Dynamics

We discuss here the functions of the Ultrabithorax domain of the bithorax complex (BX-C) of Drosophila and the role in development of the two major transcription units within this region. We use the term Ultrabithorax domain to refer to a region of the BX-C that is approximately 100 kb long. This region is not a single gene, but by genetic criteria, it forms a single functional unit (Lewis 1963, 1978; Bender et al. 1983; Beachy et al. 1985; Sanchez-Herrero et al. 1985). Within this domain, there are at least two transcription units. We follow Beachy et al. (1985) in referring to one of these as the Ultrabithorax (Ubx) transcription unit. This transcription unit spans the region of the chromosome where most mutations inactivate all functions of the Ultrabithorax domain; such mutations are described as Ubx alleles (Lewis 1963). A second transcription unit lies 5′ to the Ubx unit (Beachy et...