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Trypanosoma cruzi: Immunosuppressed response to different antigens in the infected mouse

1978; Elsevier BV; Volume: 45; Issue: 2 Linguagem: Inglês

10.1016/0014-4894(78)90059-0

1090-2449

Celso Ramos, Edmundo Lamoyi, Miguel Feoli, Miguel Á. Rodríguez, M.F. Correa Perez, L Ortíz-Ortíz,

Parasitic Infections and Diagnostics

Trypanosoma cruzi: Immunosuppressed response to different antigens in the infected mouse. Experimental Parasitology45, 190–199. Trypanosoma cruzi infection in mice results in functional changes in the normal immunological responses to heterologous antigens. An immunosuppression of the 19 and 7S antibody response is observed in infected animals against both a particulate antigen and against soluble antigens. Furthermore, the immune response to the soluble T-independent antigens, DNP-Ficoll and LPS, was also similarly impaired when antigen was administered to trypanosome-infected animals. The suppression of the immune response to these antigens does not seem to involve an alteration in the macrophage, as evidenced by a normal uptake and handling of soluble 131I-labeled HSA and by a normal immune response when antigen-exposed peritoneal macrophages from trypanosome-infected mice were transferred to normal mice. These data support the concept that T. cruzi induces an immunosuppression to both T-dependent and T-independent antigens and that the depression observed is not due to an alteration in macrophage function.