Mild Amidation of Aldehydes with Amines Mediated by Lanthanide Catalysts
2007; American Chemical Society; Volume: 10; Issue: 2 Linguagem: Inglês
10.1021/ol702788j
ISSN1523-7060
Autores Tópico(s)Click Chemistry and Applications
ResumoCatalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
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