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Mycotoxin Production by Fusarium avenaceum Strains Isolated from Norwegian Grain and the Cytotoxicity of Rice Culture Extracts to Porcine Kidney Epithelial Cells

2002; American Chemical Society; Volume: 50; Issue: 10 Linguagem: Inglês

10.1021/jf011532h

1520-5118

Ellen Morrison, Barbara Kosiak, Alberto Ritieni, Are H. Aastveit, Silvio Uhlig, Aksel Bernhoft,

Synthesis and Biological Evaluation

The secondary metabolites of 24 isolates of Fusarium avenaceum from Norwegian cereals and grown on rice have been characterized. Moniliformin (MON), enniatins (ENNs), and beauvericin (BEA) were analyzed by high-performance liquid chromatography. Porcine kidney epithelial cells (PK15, American Type Culture Collection) were used to study the cytotoxicity of MON in the extracts. The following metabolites were produced by all isolates, ranked by concentration in rice cultures: ENN-B, MON, ENN-B1, and ENN-A. BEA was produced by eight isolates. The productions of BEA and ENN-A were significantly correlated, as was the case with ENN-B and ENN-B1. MON production was correlated neither to any of the other toxins nor to toxicity.