Synthetic peptide inhibitors of complement serine proteases—I. Identification of functionally equivalent protease inhibitor sequences in serpins and inhibition of C1s and D
1988; Elsevier BV; Volume: 25; Issue: 12 Linguagem: Inglês
10.1016/0161-5890(88)90040-5
ISSN1872-9142
AutoresGeorge I. Glover, Charles S. Schasteen, S. Liu, R. P. Levine,
Tópico(s)Complement system in diseases
ResumoSequence homology comparisons between serum serine protease inhibitors led to the prediction that the C-terminal sequences are functionally equivalent and represent an essential protease binding domain. Inhibition of complement serine protease D cleavage of factor B and of C1s cleavage of C4 by synthetic peptides containing sequences from the C-termini of three serum serine protease inhibitors supports this prediction. These functionally equivalent peptides represent a new class of inhibitors of D and C1s as well as other serum serine proteases.
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