Structure–activity relationship study of synthetic hydrazines as ecdysone agonists in the control of spruce budworm ( Choristoneura fumiferana )
1995; NRC Research Press; Volume: 73; Issue: 4 Linguagem: Inglês
10.1139/v95-071
ISSN1480-3291
AutoresAnmar K. Mohammed-Ali, Tak Hang Chan, A. W. Thomas, George M. Strunz, Brent Jewett,
Tópico(s)Allelopathy and phytotoxic interactions
ResumoA quantitative structure–activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high π value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone. Keywords: spruce budworm, ecdysone, agonist, hydrazines, quantitative structure–activity relationship.
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