Electron microscope observations on rabies virus by negative staining
1962; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês
10.1016/0042-6822(62)90190-3
ISSN1096-0341
AutoresJune D. Almeida, A.F. Howatson, L. Pinteric, P Fenje,
Tópico(s)Rabies epidemiology and control
ResumoThe clinical course of human rabies virus infection can be separated into five stages: incubation, prodrome, neurological stage, coma, and death. Encephalitic rabies is reported to occur in the majority of human cases. Hyperactivity is the major sign of encephalitic rabies, appearing as anxiety, nervousness, and mental confusion, alternating with periods of lucidity and preserved intelligence. Typical encephalitic rabies is diagnosed by autonomic dysfunction, hydrophobia and aerophobia, and periods of agitation, hyperexcitation, confusion, hyporeactivity, and drowsiness. During paralytic rabies in humans, seizures are common and fever is usually high and constant. The pathology of rabies virus infection in the central nervous system has been reviewed and the only gross pathological lesion is congestion of the meningeal vessels; a mild cerebral edema is also observed. Some of the histological features of rabies virus infection are (1) a perivascular accumulation of leukocytes, primarily in the spinal cord and brainstem, (2) neuronal degeneration and neuronophagia, and (3) glial proliferation. Ganglionic lesions and cranial nerve lesions of the same kind are also said to be good indications of rabies virus infection. In humans, great variability ranging from no histological lesions to widespread inflammatory changes associated with neuronal degeneration and neuronophagia is observed.
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