Cyclosporine Delays but does not Prevent Clinical Onset in Glucose Intolerant Pre-type 1 Diabetic Children
1996; Elsevier BV; Volume: 9; Issue: 6 Linguagem: Inglês
10.1006/jaut.1996.0096
ISSN1095-9157
AutoresJean‐Claude Carel, Christian Boîtard, George S. Eisenbarth, Jean-François Bach, Pierre-François Bougnères,
Tópico(s)Diabetes Treatment and Management
ResumoWe conducted a pilot study of immunosuppression with low dose cyclosporine in first degree relatives of diabetic patients with immunologic and metabolic criteria for preclinical diabetes: islet cell antibodies (ICA) ≥20 Juvenile Diabetes Foundation (JDF) units, first phase insulin response 34±8 months,P<0.001 vs the control group; Mann–Whitney test). First phase insulin response increased to normal values in two patients. These results suggest that reversible functional impairment, in association with β-cell destruction, contributes to the failure of insulin secretion in preclinical type 1 diabetes.
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