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Potency control of modified live viral vaccines for veterinary use

1996; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês

10.1016/0264-410x(96)83467-0

1873-2518

C. Terpstra, A.H. Kroese,

Animal Disease Management and Epidemiology

This paper reviews various aspects of efficacy, and methods for assaying the potency of modified live viral vaccines. The pros and cons of parametric versus non-parametric methods for analysis of potency assays are discussed and critical levels of protection, as determined by the target(s) of vaccination, are exemplified. Recommendations are presented for designing potency assays on master virus seeds and vaccine batches.