Transcriptional diversity during lineage commitment of human blood progenitors
2014; American Association for the Advancement of Science; Volume: 345; Issue: 6204 Linguagem: Inglês
10.1126/science.1251033
ISSN1095-9203
AutoresLu Chen, Myrto Kostadima, Joost H.A. Martens, Giovanni Canu, Sara P. Garcia, Ernest Turro, Kate Downes, Iain C. Macaulay, Ewa Bielczyk-Maczyńska, S. Coe, Samantha Farrow, Pawan Poudel, Frances Burden, Sjoert B.G. Jansen, William J. Astle, Antony Attwood, Tadbir K. Bariana, Bernard de Bono, Alessandra Breschi, John C. Chambers, Fizzah Choudry, Laura Clarke, Paul Coupland, Martijn van der Ent, Wendy N. Erber, Joop H. Jansen, Rémi Favier, Matthew Fenech, Nicola Foad, Kathleen Freson, Chris Van Geet, Keith Gomez, Roderic Guigó, Daniel J. Hampshire, Anne M. Kelly, Hindrik H. D. Kerstens, Jaspal S. Kooner, Michael Laffan, Claire Lentaigne, Charlotte Labalette, Tiphaine Martin, Stuart Meacham, Andrew Mumford, Sylvia Nürnberg, Emilio Palumbo, Bert A. van der Reijden, David Richardson, Stephen‐John Sammut, Greg Slodkowicz, Asif U. Tamuri, Louella Vasquez, Katrin Voß, Stephen Watt, Sarah K. Westbury, Paul Flicek, Remco Loos, Nick Goldman, Paul Bertone, Randy J. Read, Sylvia Richardson, Ana Cvejic, Nicole Soranzo, Willem H. Ouwehand, Hendrik G. Stunnenberg, Mattia Frontini, Augusto Rendon,
Tópico(s)Cancer Genomics and Diagnostics
ResumoA BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differentiation. By inducing immune responses, Saeed et al. document the epigenetic changes in the genome that underlie immune cell differentiation. Cheng et al. demonstrate that trained monocytes are highly dependent on the breakdown of sugars in the presence of oxygen, which allows cells to produce the energy needed to mount an immune response. Chen et al. examine RNA transcripts and find that specific cell lineages use RNA transcripts of different length and composition (isoforms) to form proteins. Together, the studies reveal how epigenetic effects can drive the development of blood cells involved in the immune system. Science , this issue 10.1126/science.1251086 , 10.1126/science.1250684 , 10.1126/science.1251033
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