Rhodium(III)-Catalyzed Indazole Synthesis by C–H Bond Functionalization and Cyclative Capture
2013; American Chemical Society; Volume: 135; Issue: 19 Linguagem: Inglês
10.1021/ja402761p
ISSN1943-2984
AutoresYajing Lian, Robert G. Bergman, Luke D. Lavis, Jonathan A. Ellman,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoAn efficient, one-step, and highly functional group-compatible synthesis of substituted N-aryl-2H-indazoles is reported via the rhodium(III)-catalyzed C–H bond addition of azobenzenes to aldehydes. The regioselective coupling of unsymmetrical azobenzenes was further demonstrated and led to the development of a new removable aryl group that allows for the preparation of indazoles without N-substitution. The 2-aryl-2H-indazole products also represent a new class of readily prepared fluorophores for which initial spectroscopic characterization has been performed.
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