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Cellulose Acetate Butyrate and Polycaprolactone for Ketoprofen Spray-Dried Microsphere Preparation

1994; Taylor & Francis; Volume: 11; Issue: 4 Linguagem: Inglês

10.3109/02652049409034256

1464-5246

Paolo Giunchedi, Bice Conti, Lauretta Maggi, U. Conte,

Drug Solubulity and Delivery Systems

Ketoprofen-loaded microspheres made with a polymeric blend were prepared by a spray-drying technique. Organic solutions of two polymers, cellulose acetate butyrate (CAB) and poly(ε-caprolactone) (PCL), in different weight ratios, and of ketoprofen (Ket) were prepared and sprayed, in different experimental conditions, achieving drug-loaded microspheres. The obtained spray-dried microspheres were characterized in terms of yield of production, shape, size, surface properties and drug content, and their in vitro drug release behaviours were determined at different pH values.