ERECTILE RESPONSE TO TRANSURETHRAL ALPROSTADIL, PRAZOSIN AND ALPROSTADIL-PRAZOSIN COMBINATIONS
1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 5 Linguagem: Inglês
10.1097/00005392-199805000-00030
ISSN1527-3792
AutoresCraig A. Peterson, Alan H. Bennett, Wayne J.G. Hellstrom, Fran E. Kaiser, John E. Morley, Kerry J. Nemo, Harin Padma-Nathan, Virgil A. Place, J. Joseph Prendergast, PETER Y. TAM, Emil A. Tanagho, Leslie Todd, John Varady, Neil Gesundheit,
Tópico(s)Hormonal and reproductive studies
ResumoNo AccessJournal of UrologyClinical Urology: Original Articles1 May 1998ERECTILE RESPONSE TO TRANSURETHRAL ALPROSTADIL, PRAZOSIN AND ALPROSTADIL-PRAZOSIN COMBINATIONS CRAIG A. PETERSON, ALAN H. BENNETT, WAYNE J.G. HELLSTROM, FRAN E. KAISER, JOHN E. MORLEY, KERRY J. NEMO, HARIN PADMA-NATHAN, VIRGIL A. PLACE, J. JOSEPH PRENDERGAST, PETER Y. TAM, EMIL A. TANAGHO, LESLIE K. TODD, JOHN C. VARADY, and NEIL GESUNDHEIT CRAIG A. PETERSONCRAIG A. PETERSON , ALAN H. BENNETTALAN H. BENNETT , WAYNE J.G. HELLSTROMWAYNE J.G. HELLSTROM , FRAN E. KAISERFRAN E. KAISER , JOHN E. MORLEYJOHN E. MORLEY , KERRY J. NEMOKERRY J. NEMO , HARIN PADMA-NATHANHARIN PADMA-NATHAN , VIRGIL A. PLACEVIRGIL A. PLACE , J. JOSEPH PRENDERGASTJ. JOSEPH PRENDERGAST , PETER Y. TAMPETER Y. TAM , EMIL A. TANAGHOEMIL A. TANAGHO , LESLIE K. TODDLESLIE K. TODD , JOHN C. VARADYJOHN C. VARADY , and NEIL GESUNDHEITNEIL GESUNDHEIT View All Author Informationhttps://doi.org/10.1097/00005392-199805000-00030AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Transurethral alprostadil has been shown to be efficacious in many men with erectile dysfunction. We compared transurethral alprostadil and prazosin alone, and in combination to treat this disorder. Materials and Methods: In this double-blind, placebo controlled study the erectile responses to transurethral alprostadil, prazosin and alprostadil-prazosin combinations were assessed in 234 men 26.8 to 8.15 years old with complete organic erectile dysfunction. Patients self-administered a random sequence of 7 doses in the clinic in 4 weeks. The erectile response was assessed using categorical and visual analog scales. Results: Full penile enlargement or rigidity was achieved by 165 of the 234 men (70.5%) after at least 1 active dose of medication. The most effective alprostadil dose (500 micro g.) resulted in full penile enlargement or rigidity in 51.8% of administrations, whereas the most effective prazosin dose (2,000 micro g.) and placebo resulted in a similar response in 12.7 and 2.7%, respectively (p <0.001). The 500/2,000 micro g. alprostadil/prazosin combination, which resulted in full enlargement or rigidity in 58.9% of doses, was only slightly better than the most effective dose of alprostadil alone (500 micro g.). However, combinations of 125/500 and 250/500 micro g. alprostadil/prazosin were more effective (p <0.01) than 125 and 250 micro g. alprostadil given alone, respectively. The most common side effect of therapy was penile pain, which rarely led to study discontinuation. Hypotension most commonly developed at the higher alprostadil-prazosin combination. 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Google Scholar From the Department of Clinical Research, VIVUS, Inc., Menlo Park, Department of Urology, University of Southern California, Los Angeles, The Male Clinic, Santa Monica, Pacific Medical Research Services, Atherton and Department of Urology, University of California, San Francisco, California, Division of Urology, Albany Medical College, Albany, New York, Department of Urology, Tulane University, New Orleans, Louisiana, and Division of Geriatric Medicine, St. Louis University School of Medicine and Geriatric Research Education and Clinical Center, St. Louis Veterans Affairs Medical Center, St. Louis, Missouri.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBENEVIDES M and CARSON C (2018) INTRAURETHRAL APPLICATION OF ALPROSTADIL IN PATIENTS WITH FAILED INFLATABLE PENILE PROSTHESISJournal of Urology, VOL. 163, NO. 3, (785-787), Online publication date: 1-Mar-2000. Volume 159Issue 5May 1998Page: 1523-1528 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information CRAIG A. PETERSON More articles by this author ALAN H. BENNETT More articles by this author WAYNE J.G. HELLSTROM More articles by this author FRAN E. KAISER More articles by this author JOHN E. MORLEY More articles by this author KERRY J. NEMO More articles by this author HARIN PADMA-NATHAN More articles by this author VIRGIL A. PLACE More articles by this author J. JOSEPH PRENDERGAST More articles by this author PETER Y. TAM More articles by this author EMIL A. TANAGHO More articles by this author LESLIE K. TODD More articles by this author JOHN C. VARADY More articles by this author NEIL GESUNDHEIT More articles by this author Expand All Advertisement PDF downloadLoading ...
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