A New HLA‐B Antigen, BHT: Definition by Serological and Biochemical Means
1989; Wiley; Volume: 56; Issue: 4 Linguagem: Inglês
10.1111/j.1423-0410.1989.tb02042.x
ISSN1423-0410
AutoresA Hajek-Rosenmayr, Lisi Jungl, M. Kirnbauer, Gerhard Grüber, Wolfgang R. Mayr,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoAbstract. In 3 unrelated individuals, a new, so far unknown HLA‐B‐locus antigen was found. This HLA‐B antigen, provisionally termed ‘BHT’, is recognized by extra reactions with alloantisera against the B5 cross‐reactive group. BHT can be clearly discerned from all cross‐reactive antigens by one‐dimensional isoelectro focusing (1D IEF), as it reveals, on IEF gels, a characteristic, rather neutral double‐banding pattern different from all known HLA class I bands. The BHT banding pattern, which is identical in all 3 BHT‐positive individuals, segregates with the haplotype A28, BHT, Cw7, DRw6.
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