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Emphysema as a Risk Factor for the Outcome of Surgical Resection of Lung Cancer

2010; Korean Academy of Medical Sciences; Volume: 25; Issue: 8 Linguagem: Inglês

10.3346/jkms.2010.25.8.1146

1598-6357

Sung Ah Lee, Joo Sung Sun, Joo Hun Park, Kyung Joo Park, Sungsoo Lee, Ho-Chun Choi, Seung Soo Sheen, Woo Young Chung, Keu Sung Lee, Kwang Joo Park, Sung Chul Hwang,

Lung Cancer Diagnosis and Treatment

Emphysema as a Risk Factor for the Outcome of Surgical Resection of Lung CancerIt is unclear whether emphysema, regardless of airflow limitation, is a predictive factor associated with survival after lung cancer resection.Therefore, we investigated whether emphysema was a risk factor associated with the outcome after resection for lung cancer.This study enrolled 237 patients with non small cell lung cancer with stage I or II who had surgical removal.Patient outcome was analyzed based on emphysema.Emphysema was found in 43.4% of all patients.Patients with emphysema were predominantly men and smokers, and had a lower body mass index than the patients without emphysema.The patients without emphysema (n=133) survived longer (mean 51.2±3.0 vs. 40.6±3.1 months, P=0.042) than those with emphysema (n=104).The univariate analysis showed a younger age, higher FEV1/FVC, higher body mass index, cancer stage I, and a lower emphysema score were significant predictors of better survival.The multivariate analysis revealed a younger age, higher body mass index, and cancer stage I were independent parameters associated with better survival, however, emphysema was not.This study suggests that unfavorable outcomes after surgical resection of lung cancer should not be attributed to emphysema itself.