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Revisão Revisado por pares
BIBTEX RIS

GABA receptor function and pharmacology in epilepsy and status epilepticus

2003; Elsevier BV; Volume: 3; Issue: 1 Linguagem: Inglês

10.1016/s1471-4892(02)00015-2

ISSN

1471-4973

Autores

Dorothy M. Jones, R MACDONALD,

Tópico(s)

Ion channel regulation and function

Resumo

GABAA (γ-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABAA receptors in seizure disorders. In particular, genetic mutations found in GABAA receptor subunits strongly implicate the GABAA receptor in idiopathic generalised epilepsies.

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