A Double-blind Controlled Comparison of Generic and Trade-Name Topical Steroids Using the Vasoconstriction Assay
1991; American Medical Association; Volume: 127; Issue: 2 Linguagem: Inglês
10.1001/archderm.1991.01680020065006
ISSN1538-3652
Autores Tópico(s)Contact Dermatitis and Allergies
Resumo• Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay. ( Arch Dermatol. 1991;127:197-201)
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