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Revisão Revisado por pares
BIBTEX RIS

The DNA polymerase α-primase complex couples DNA replication, cell-cycle progression and DNA-damage response

1997; Elsevier BV; Volume: 22; Issue: 11 Linguagem: Inglês

10.1016/s0968-0004(97)01109-2

ISSN

1362-4326

Autores

Marco Fioani, Giovanna Lucchini, Paolo Plevani,

Tópico(s)

Cancer-related Molecular Pathways

Resumo

The highly conserved DNA polymerase α-primase complex (pol-prim) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.

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