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Casearin X, Its Degradation Product and Other Clerodane Diterpenes from Leaves of Casearia sylvestris: Evaluation of Cytotoxicity against Normal and Tumor Human Cells

2010; Wiley; Volume: 7; Issue: 1 Linguagem: Inglês

10.1002/cbdv.200800342

1612-1880

André Gonzaga dos Santos, Paulo Michel Pinheiro Ferreira, Gerardo Magela Vieira Júnior, Carla Cristina Perez, Aristeu Gomes Tininis, Geraldo Humberto Silva, Vanderlan da Silva Bolzani, Letícia V. Costa‐Lotufo, Cláudia do Ó Pessoa, Alberto José Cavalheiro,

Plant-Derived Bioactive Compounds

Abstract An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, casearin X, together with the known compounds casearins B, D, L, and O, and caseargrewiin F. Casearin X degraded to the corresponding dialdehyde when stored in CDCl 3 . The diterpenes isolated were cytotoxic to human cancer cell lines, with caseargrewiin F being the most active and the new clerodane, casearin X, the second active compound with IC 50 values comparable to the positive control doxorubicin. All isolated diterpenes showed lower activities against normal human cells than against cancer cell lines, which might indicate a possible selective action on cancer cells. Casearin X dialdehyde was not cytotoxic to cancer cells indicating that the occurrence of these CO groups at C(18) and C(19) is incompatible with the cytotoxic activity.