Peripheral Neuropathy Associated With Antiglutamic Acid Decarboxylase Antibodies
2013; Elsevier BV; Volume: 48; Issue: 5 Linguagem: Inglês
10.1016/j.pediatrneurol.2012.12.031
ISSN1873-5150
AutoresSema Saltık, Muzaffer Türkeş, Erdem Tüzün, Arif Cakır, Canan Ulusoy,
Tópico(s)Hereditary Neurological Disorders
ResumoAutoantibodies to glutamic acid decarboxylase are found in some rare neurological diseases. However, acute peripheral neuropathy associated with antiglutamic acid decarboxylase autoimmunity has not been reported previously. Here we report a case of a patient who presented with acute cranial and peripheral neuropathy in association with the presence of serum antiglutamic acid decarboxylase antibodies. A 13-year-old boy was admitted to our pediatric neurology clinic with diplopia due to sixth cranial nerve palsy and ascending motor weakness in all extremities. The nerve conduction studies showed bilateral motor and sensory demyelinating neuropathy. Full recovery was achieved following intravenous immunoglobulin treatment. Glutamic acid decarboxylase autoimmunity–associated neurological diseases spectrum may also include acute demyelinating peripheral neuropathy.
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