Cryptococcus neoformans Infection in Patients With Cirrhosis, Including Liver Transplant Candidates
2004; Wolters Kluwer; Volume: 83; Issue: 3 Linguagem: Inglês
10.1097/01.md.0000126760.45299.69
ISSN1536-5964
AutoresNina Singh, Shahid Husain, Michael de Vera, Timothy Gayowski, Thomas V. Cacciarelli,
Tópico(s)Neutropenia and Cancer Infections
ResumoWe reviewed the cases of patients with cirrhosis, including liver transplant candidates, at our institution in the last 3 years (n = 5) and those individually described in the literature (n = 28), to assess unique characteristics and outcome of cryptococcosis in these patients. Sixty-four percent (21/33) of the patients had no other recognized immunosuppression. Peritonitis (in 45%, 15/33 of the patients) with modest pleocytosis in the ascitic fluid, was the most common presenting feature. Median time to detection of Cryptococcus in the ascitic fluid cultures was 6 days. Overall mortality rate was 81% (26/32); death was deemed attributable to cryptococcosis in 24/26 patients who died. Evaluation of culture-negative neutrocytic ascites in febrile cirrhotic patients warrants consideration of cryptococcal peritonitis.
Referência(s)