Portal de Periódicos da CAPES

Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: a report of the CHAMP Study Group

2000; Wiley; Volume: 37; Issue: 3 Linguagem: Inglês

10.1046/j.1365-2559.2000.00947.x

1365-2559

Roberta Vanni, Christopher D.�M. Fletcher, Raf Sciot, Paola Dal Cin, Ivo De Wever, Nils Mandahl, Fredrik Mertens, Felix Mitelman, Juan Rosaí, Anders Rydholm, Giovanni Tallini, Herman Van den Berghe, Helena Willén,

Histiocytic Disorders and Treatments

Cutaneous benign fibrohistiocytic tumours are among the most common soft tissue lesions. Their biological nature, in particular whether they are neoplastic or reactive, has long been disputed. Some morphological subtypes can be confused with sarcoma. Since available karyotypic data in these lesions are scarce, this study was undertaken to determine whether their cytogenetic analysis might demonstrate clonality and might help in differential diagnosis.Thirteen karyotyped benign cutaneous fibrous histiocytomas (BFH) were morphologically reassessed and classified as ordinary BFH (eight cases), cellular BFH (four cases), and one ankle-type lesion. Five cases (38%) showed clonal cytogenetic changes, although the aberrations varied and did not correlate with histological subtypes. Karyotypic aberrations were more common in cellular BFH (3/4) than in the ordinary BFH (2/8).The demonstration of clonal chromosome abnormalities, in at least some cases, supports the neoplastic nature of cutaneous BFH. The karyotypic changes identified are different from those in dermatofibrosarcoma, with which cellular BFH is often confused histologically.