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BIBTEX RIS

Protective effects of Croton campestris A. St-Hill in different ulcer models in rodents: Evidence for the involvement of nitric oxide and prostaglandins

2014; Elsevier BV; Volume: 153; Issue: 2 Linguagem: Inglês

10.1016/j.jep.2014.03.005

ISSN

1872-7573

Autores

Francisco Elizaudo de Brito, Dayanne Rakelly de Oliveira, Aline Augusti Boligon, Margareth Linde Athayde, Jean Paul Kamdem, Giulianna Echeverria Macedo, Gustavo Felipe da Silva, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Marta Regina Kerntopf, Thaís Posser,

Tópico(s)

Essential Oils and Antimicrobial Activity

Resumo

Croton campestris A. St.-Hill., popularly known as "velame do campo", is a species native from savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for a variety of health problems, especially detoxification, inflammation and gastritis. The present study investigates the possible gastric antiulcer activity of Croton campestris root extract (CCRE) and mechanisms of action underlying this effect. Gastric lesions were induced in mice by ethanol, acidified ethanol and indomethacin. CCRE was previously administered orally in doses ranging from 50 to 750 mg/kg. Stomach lesions were measured. The involvement of Nitric Oxide (NO), prostaglandins (PGEs), ATP-dependent K+ channel and adrenergic receptor was investigated through specific inhibitors. CCRE produced significant antiulcer activity against absolute ethanol, acidified ethanol and indomethacin induced gastric lesions. The pretreatment with L-NAME (10 mg/kg, p.o.), an inhibitor of nitric oxide synthesis and indomethacin (10 mg/kg, s.c.), an inhibitor of prostaglandin production, reversed the antiulcer action of CCRE. Taking together, these results suggest that the antiulcer activity of CCRE is dependent of NO and prostaglandin pathways possibly due to its ability to stimulate the synthesis of NO, and activation of endogenous prostaglandin production. Therefore, the use of CCRE in traditional Brazilian medicine against gastric disorders has a scientific basis.

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