Portal de Periódicos da CAPES

The cognitive principle challenges clonal selection

1992; Elsevier BV; Volume: 13; Issue: 11 Linguagem: Inglês

10.1016/0167-5699(92)90071-e

1355-8242

Irun R. Cohen,

SARS-CoV-2 and COVID-19 Research

Here, Irun Cohen argues that the clonal selection paradigm is no longer a convenient paradigm for organizing thinking about the immune system. He contends that most immunologists now investigate questions for which the clonal selection paradigm makes no provision and that one of its major tenets is contradicted by the prevalence of natural autoimmunity. Instead, he proposes a cognitive paradigm.