Artigo Revisado por pares

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

2006; Wiley; Volume: 49; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2559.2006.02515.x

ISSN

1365-2559

Autores

Sundaram Challa, Umabala Pamidimukkala, Vijay Laxmi, A. K. Purohit, V S S V Prasad, Manas Panigrahi, B Sahu, M V Sarathi, Subhash Kaul, Rupam Borghain, AK Meena, Sita Jayalakshmi, A Suvarna, Sukhada Mohandas, J. M. K. Murthy,

Tópico(s)

Infectious Diseases and Mycology

Resumo

Aims: To describe the pathology of central nervous system (CNS) fungal infections with particular reference to India. Methods and results: This was a retrospective study from 1988 to 2004 constituting 130 cases. The diagnosis was based on morphology of biopsy/autopsy material. These included aspergillosis ( n = 73), zygomycosis ( n = 40), cryptococcosis ( n = 2), rhodotorulosis ( n = 1), candidiasis ( n = 5), maduramycosis ( n = 1), pheohyphomycosis ( n = 3) and mixed infections ( n = 5). Predisposing risk factors were present in 49 (38%) patients only. The majority of the patients were immunocompetent. The commonest risk factor was diabetes mellitus, the commonest route of infection was from a contiguous site and the commonest pathology was granuloma. Culture positivity was seen in only 31%. Conclusion: Environmental factors in tropical countries such as India play a significant role in the pathogenesis of CNS fungal infections.

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