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Neoadjuvant chemotherapy and conservative surgery for stage IB1 cervical cancer

2008; Elsevier BV; Volume: 111; Issue: 3 Linguagem: Inglês

10.1016/j.ygyno.2008.08.023

1095-6859

Andrea Maneo, Stefania Chiari, Cristina Bonazzi, Costantino Mangioni,

Endometriosis Research and Treatment

To assess the effectiveness of chemo-surgical conservative therapy for stage IB1 cervical tumors in patients desiring to preserve fertility.From 1995 to April 2007 51 nulliparous patients with tumor <or=3 cm, aged 3 mm in 4. Four women deemed ineligible for conservative surgery after chemotherapy and one refusing to preserve her genital apparatus underwent radical hysterectomy. After a median follow-up of 69 months no relapses were observed. Nine women attempted to conceive: ten pregnancies occurred in 6 patients and 9 live babies have been born, while one woman experienced a first-trimester miscarriage.The high rate of pathological response confirms the effectiveness of the preoperative treatment for reducing the tumor volume allowing the removal only of a cervical cone instead of the entire cervix with cardinal ligaments as needed by radical trachelectomy. Successful pregnancies are possible after such integration.