Synthesis of acyclic polyol derivatives via enzyme-mediated aldol reaction
1993; Elsevier BV; Volume: 34; Issue: 31 Linguagem: Inglês
10.1016/s0040-4039(00)74050-0
ISSN1873-3581
AutoresKazutsugu Matsumoto, M. SHIMAGAKI, Tadashi Nakata, Takeshi Oishi,
Tópico(s)Chemical Synthesis and Analysis
ResumoEnzyme-mediated stereoselective aldol reaction between dihydroxyacetone phosphate (DHAP, 1) and (2R,4R)-6-benzyloxy-2,4-dimethoxyhexanal (8) was catalyzed by rabbit muscle aldolase (RAMA) to generate (3S,4R,5R,7R)-trihydroxyketone 12, which could be easily transformed to the masked polyhydroxylated compound 15 corresponding to the C-9∼C-16 segment of pentamycin (6).
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