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BIBTEX RIS

Lack of control of severe asthma is associated with co‐existence of moderate‐to‐severe rhinitis

2008; Wiley; Volume: 63; Issue: 5 Linguagem: Inglês

10.1111/j.1398-9995.2007.01624.x

1398-9995

Eduardo Vieira Ponte, Rosana Franco, Harrison Floriano do Nascimento, Adelmir Souza‐Machado, Sérgio Souza da Cunha, Maurício L. Barreto, Charles K. Naspitz, Álvaro A. Cruz,

Respiratory and Cough-Related Research

Background: Retrospective studies provide evidence that rhinitis is associated with more severe asthma. The aim of this study was to evaluate prospectively whether rhinitis is a predictor of increased asthma severity. Methods: Five hundred and fifty‐seven patients with severe asthma were enrolled. During 1 year of follow‐up, each patient was evaluated every 3 months with a record of emergency room visits and supply of topical corticosteroids for asthma and rhinitis. In the 1 year of follow‐up visit, the patients were checked for rhinitis diagnosis, severity and answered questionnaires for asthma symptoms and quality of life. Results: Eighty‐two (15%) patients had no rhinitis, 299 (54%) had mild rhinitis and 176 (31%) moderate/severe rhinitis. In logistic regression models, moderate/severe rhinitis was a predictor for any emergency room visit in the follow‐up period [3.83 (2.00–7.35)], for the presence of uncontrolled asthma after 1 year of follow‐up [12.68 (1.73–92.85)], for <10% improvement of the airway obstruction [2.94 (1.48–5.85)] and <50% reduction in the number of emergency room visits [2.90 (1.02–8.26)] in the year of follow‐up. It was also associated with a smaller chance of more than 90% reduction in the number of emergency room visits in the year of follow‐up [0.27 (0.12–0.60)]. In a multivariate linear regression model, severity of rhinitis was positively correlated with a score of asthma severity and inversely correlated to an index of quality of life. Conclusions: In a population with severe asthma, moderate/severe rhinitis is a strong predictor for greater severity of asthma.