Portal de Periódicos da CAPES

APC, Signal transduction and genetic instability in colorectal cancer

2001; Nature Portfolio; Volume: 1; Issue: 1 Linguagem: Inglês

10.1038/35094067

1474-1768

Riccardo Fodde, Ron Smits, Hans Clevers,

Cancer-related Molecular Pathways

Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC — the gene responsible for most cases of colorectal cancer — might fulfil both requirements.