Portal de Periódicos da CAPES

Bromomaleimides: new reagents for the selective and reversible modification of cysteine

2009; Royal Society of Chemistry; Issue: 43 Linguagem: Inglês

10.1039/b915136b

1364-548X

Lauren Tedaldi, Mark E. B. Smith, Ramiz I. Nathani, James R. Baker,

Click Chemistry and Applications

Bromomaleimides react rapidly and selectively with cysteine to afford thiomaleimides which can be cleaved with a phosphine to regenerate the cysteine or treated with a base to afford dehydroalanine.