Epstein-Barr Virus Susceptibility of B Cells Correlates to the Presence of Complement Receptors but not Surface Immunoglobulins
1981; Karger Publishers; Volume: 16; Issue: 2 Linguagem: Inglês
10.1159/000149256
ISSN1423-0100
Autores Tópico(s)Parvovirus B19 Infection Studies
ResumoNuclear antigen (EBNA) inducibility by Epstein-Barr virus (EBV) was assessed in relation to the presence of complement (C3) receptors and surface immunoglobulins (SIg) on leukemic lymphocytes. When erythrocyte-antibody-complement complex(EAC)-positive, SIg-negative B cells were exposed to EBV, EBNA synthesis occurred with a high frequency. In contrast, no significant EBNA induction was evident in SIg-positive, EAC-negative B cells. Cells possessing both markers were EBV-infectable, in proportion to the frequency of EAC-rosette formation. These data seem to indicate that EBV susceptibility of human B cells is closely related to the presence of C3 receptors but not SIg. Leukemic T cells and myelogenous leukemia cells were not EBV-susceptible, although some cells were significantly positive for C3 receptors.
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