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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives

2012; Elsevier BV; Volume: 20; Issue: 11 Linguagem: Inglês

10.1016/j.bmc.2012.04.007

ISSN

1464-3391

Autores

Francisco W.A. Barros, Teresinha Gonçalves da Silva, Marina Galdino da Rocha Pitta, Daniel P. Bezerra, Letícia V. Costa‐Lotufo, Manoel Odorico de Moraes, Cláudia Pessoa, Maria Aline Barros Fidelis de Moura, Fabiane C. de Abreu, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Marília Oliveira Fonseca Goulart,

Tópico(s)

Bioactive Compounds and Antitumor Agents

Resumo

Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques.

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