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When ribosomes go bad: diseases of ribosome biogenesis

2010; Royal Society of Chemistry; Volume: 6; Issue: 3 Linguagem: Inglês

10.1039/b919670f

1742-206X

Emily F. Freed, Franziska Bleichert, Laura M. Dutca, Susan J. Baserga,

RNA and protein synthesis mechanisms

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of these complexes. However, in the last few decades, a number of diseases of ribosome biogenesis have been discovered. It remains a challenge in the field to elucidate the molecular mechanisms underlying them.