A general approach to the enantiomeric synthesis of lipidic α-amino acids, peptides and vicinal amino alcohols
1996; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês
10.1016/0957-4166(96)00084-5
ISSN1362-511X
AutoresGeorge Kokotos, José M. Padrón, Caterina Noula, William A. Gibbons, Victor S. Martı́n,
Tópico(s)Analytical Chemistry and Chromatography
ResumoAbstract A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino alcohols and homo- and hetero-peptides.
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