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Biologically active heparin-like fragments with a “non-glycosamino”glycan structure. Part 3 : o-alkylated-o-sulphated pentasaccharides.

1992; Elsevier BV; Volume: 2; Issue: 9 Linguagem: Inglês

10.1016/s0960-894x(00)80585-5

1464-3405

Jan E. M. Basten, Guy Jaurand, B. Olde-Hanter, Philippe Duchaussoy, M. Petitoub, C. A. A. VAN BOECKEL,

Fibroblast Growth Factor Research

The synthesis of analogues of biologically active heparin pentasaccharide fragments is reported. Replacement of N-sulphate by O-sulphate esters and introduction of various O-alkyl ethers resulted in biologically active “non-glycosamino“glycans. The biological activity can be further modulated by changing the nature and the position of the alkyl chains introduced.