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The intralobular framework of the human spleen

1901; Wiley; Volume: 1; Issue: 1 Linguagem: Inglês

10.1002/aja.1000010103

1553-0795

Preston Kyes,

Abdominal Trauma and Injuries

The coarser framework of the human spleen divides the organ into small masses of parenchyma-the lobules, each having an afferent artery near its center and the larger efferent veins a t its periphery.The finer framework of the spleen subdivides each lobule and supports the individual spleen cells and smaller blood-vessels contained therein.The finer framework is an extension within the lobule of the coarser framework of the trabeculze and is here indicated as the intralobular framework. HISTORY.Oeaterlen; writing in 18-13, mentioned, without description, a substance between the individual cells of the spleen pulp.Atto Tigri,' in 1853, described as a constant element of strncture an intercellular network giving support to the spleen cells.Billroth,' in 1857, confirmed the presence of this intercellular framework, and described its minute structure more in detail.From a comparative study of the vertebrata, he concluded that the framework was formed by stellate cells whose anastomosing processes appeared as fibers connecting the cell bodies proper with one another.Thus, according to Billroth, the cell bodies appeared as local expansions of the fibrils, each containing a definite nucleus.From the spleens of amphibia he isolated stellate cells that he asserted were the branched cells forming the intralobular framework.From the human spleen, however, he could not isolate the corresponding cells, and stated that their demonstration i n situ was more difficult than in lower forms because of their relative infrequency.