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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children

2011; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês

10.1016/j.micinf.2011.11.008

ISSN

1769-714X

Autores

Fabrício Freire de Melo, Andréia Maria Camargos Rocha, Gifone Aguiar Rocha, Sílvia Helena Sousa Pietra Pedroso, Sérgio de Assis Batista, Lúcia Porto Fonseca de Castro, Simone Diniz Carvalho, Paulo Fernando Souto Bittencourt, Rodrigo Cardoso de Oliveira, Rodrigo Corrêa‐Oliveira, Dulciene Maria Magalhães Queiroz,

Tópico(s)

IL-33, ST2, and ILC Pathways

Resumo

Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T(reg) cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T(reg)-associated cytokines of children and adults. IL-6, IL-10 and TGF-β1 levels and Foxp3(+) cell numbers were higher, but IL-1β, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T(reg) instead of Th17 cell response to H. pylori-infection predominates in children.

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