Lesion of the nucleus basalis magnocellularis does not affect cerebral cortical blood flow in rats
1991; Elsevier BV; Volume: 12; Issue: 3 Linguagem: Inglês
10.1016/0168-0102(91)90079-e
ISSN1872-8111
AutoresHiroki Namba, Toshiaki Irie, Kiyoshi Fukushi, Toshiro Yamasaki, Yukio Tateno, Shuji Hasegawa,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoThe effects of a unilateral ibotenic acid lesion of the nucleus basalis magnocellularis (NBM) on blood flow of the cerebral cortex and striatum were studied at 2, 4, 8 and 16 weeks after the lesion in conscious rats. In the cerebral cortex, no side-to-side difference in blood flow was observed, though cholinergic enzyme activity was markedly reduced on the side of the lesion. The results suggest that NBM lesion produces disturbance of cholinergic neurons in the cerebral cortex without significant alteration of blood flow.
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